Oct
19
2009
Lupus, which means “wolf” in Latin, gets its name from the skin manifestations sometimes seen in the disease. A physician in the 13th century thought they looked like wolf bites.
In autoimmune disorders, the immune system — which normally protects us from harmful, foreign substances — goes into overdrive and starts attacking the body’s own cells, [...]
Tags: Asian, Chinese, European, lupus, Nature Genetics, systemic lupus erythematosus
Oct
16
2009
Previously in The Spittoon, we discussed two papers that identified genetic variants associated with hemoglobin levels in circulating blood.
But blood consists of much more than hemoglobin, and it is responsible for much more than just transporting oxygen. This week Nature Genetics published the results of two of the largest blood studies to date, which together [...]
Tags: blood, coronary artery disease, Hb, Hct, human evolution, MCH, MCV, MPV, Nature Genetics, PLT, RBC
Oct
12
2009
Doctors routinely order the complete blood count (CBC) for their patients because they can learn a lot about a person’s health by measuring the numbers of different types of blood cells in the circulation, their sizes and the ratios between them.
One component of the CBC is usually a measure of the total amount of hemoglobin, [...]
Tags: anemia, blood, CBC, hemochromatosis, hemoglobin, Nature Genetics
Oct
05
2009
Our bones are amazing structures, capable of supporting tremendous force through complex motions. They do this day in and day out, year after year as we sit, stand, walk, run, lift, work, and play. But as the elderly among us know all too well, bones are not invincible and become more fragile as we age. [...]
Tags: bone mineral density, Nature Genetics, osteoporosis, SNPwatch, women
Sep
29
2009
In the United States, prostate cancer affects about one in every six men. Genomewide association studies aimed at finding common genetic variants associated with this common disease have been particularly successful. More than a dozen SNPs have been associated with prostate cancer, but researchers calculate that these variants represent only a tiny fraction of the [...]
Tags: 8q24, Nature Genetics, prostate cancer
Sep
18
2009
Unlike the flu virus, which the body is generally able to fight off completely, infection with hepatitis C is often chronic. That means for most of the three to four million people worldwide who are newly infected each year the virus will persist in the body, where it greatly increases risk for chronic liver [...]
Tags: drug development, IL28B, Nature, Nature Genetics
Sep
10
2009
Scientists are narrowing in on two regions of the human genome that could be responsible for ALS (amyotrophic lateral sclerosis), also known as Lou Gehrig’s disease.
ALS is a neurodegenerative disorder that weakens muscles and paralyzes patients within three years of onset, and has no known cure. The available drug treatment delays progression by only three [...]
Tags: ALS, Lou Gehrig's Disease, Nature Genetics, UNC13A
Aug
20
2009
SNPwatch gives you the latest news about research linking various traits and conditions to individual genetic variations. These studies are exciting because they offer a glimpse into how genetics may affect our bodies and health; but in most cases, more work is needed before this research can provide information of value to individuals. For that [...]
Tags: ALL, ARID5B, IKZF1, leukemia, methotrexate, Nature Genetics
Aug
03
2009
SNPwatch gives you the latest news about research linking various traits and conditions to individual genetic variations. These studies are exciting because they offer a glimpse into how genetics may affect our bodies and health; but in most cases, more work is needed before this research can provide information of value to individuals. For that [...]
Tags: blood type, Nature Genetics, pancreatic cancer
Jun
18
2009
It’s no secret that obesity rates are rising — quickly. Between 2000 and 2005 the prevalence of obesity rose by 24%. Extreme obesity increased by more than 50%. If current trends continue, more than half of all Americans will be clinically obese by the year 2030.
Rapid changes in the prevalence of a disorder suggest that [...]
Tags: copy number variant, environment, epigenetics, Nature, Nature Genetics, nurture, obesity, sequencing, SNP