Aug
06
2009
Not long after Karl Landsteiner first described the different ABO blood types, scientists started looking for associations between blood type and other human traits. Some of their theories were truly weird (more on these tomorrow!), but some have held up to scientific scrutiny.
Venous Thromboembolism (VTE)
People with non-type O blood (A, B and AB) have been [...]
Tags: blood, blood type, cancer, infectious disease, Malaria, ulcers, vte
Jun
24
2009
Malaria, a strong evolutionary pressure in humans, has also shaped the baboon genome, new research says.
Each year at least 350 million people around the world are infected by malaria parasites. More than one million people, mainly young children, succumb to the disease. But these numbers would be even higher if it weren’t for genetic adaptations [...]
Tags: baboon, DARC, Duffy, Kenya, Malaria
May
26
2009
Malaria is one of the leading causes of death in the developing world, claiming nearly a million victims each year. The great majority of them are African children below the age of five. The illness is caused by a single-celled parasite called Plasmodium that is transmitted by mosquito bites to humans. In a paper published [...]
Tags: Africa, GWAS, hemoglobin, Malaria, Nature Genetics, The Gambia
Jul
22
2008
Last week in the Spittoon we reported on a new study that identified an interesting genetic trade-off — a genetic variant known that has one effect on a person’s vulnerability to malaria, and the opposite on susceptibility to HIV infection. The “Duffy negative” version of the gene, which is common among Africans and African Americans, [...]
Tags: diet, hemochromatosis, human evolution, Malaria, sickle-cell anemia
Jul
01
2008
Last month I had the opportunity to go to the Society of Molecular Biology and Evolution conference in the striking city of Barcelona. This is the premiere conference for geneticists studying evolution in everything from bacteria to fruit flies, weeds, worms and our favorite model organism, humans! This is a highly interactive conference: almost everyone [...]
Tags: Duffy, evolution, FOXP2, genetics, HapMap, HGDP, Imprinting, Lactose Intolerance, LCT, Malaria, SMBE