Jan
26
2010
By Nick Eriksson, 23andMe Principal Scientist, and Lizzie Dorfman, Parkinson’s Research Project Manager
Less than a year ago we announced the launch of the 23andMe Parkinson’s Research Initiative. Since then, we have built one of the world’s most useful resources for studying the genetics of Parkinson’s disease. This past December we had meetings with the National [...]
Tags: community, FasterCures, GBA, LRRK2, MAPT, Michael J. Fox Foundation, NIH, Parkinson's Disease, PatientsLikeMe, SNCA, surveys, The Cure Parkinson's Trust, The National Parkinson Foundation, The Northwest Parkinson's Foundation, The Parkinson's Institute
Oct
15
2009
Here’s how it goes for me: a few afternoons a year, usually when I haven’t slept or eaten right, but sometimes for no apparent reason, I begin to sense a pressure behind my left eyebrow and to feel queasy. By now I know what’s coming, and I resign myself to another miserable evening and a [...]
Tags: 23andWe, headache, migraine, survey
Jul
27
2009
Mutations are bad, right?
Not always. Some DNA changes are completely neutral. That’s how the human genome came to have so many variations. And some mutations are actually advantageous.
A case in point is the PCSK9 gene. So-called “loss-of-function” mutations that prevent the protein encoded by this gene from functioning properly actually lead to lower cholesterol levels.
Researchers [...]
Tags: Alynylam, Amgen, cholesterol, Isis, LDL, PCSK9
Jul
20
2009
It may be you’ve heard a rumor that males are on the brink of extinction.
Whatever you may think of that prospect, the rumor is false. But over the past decade, numerous studies have hinted that the Y chromosome, a male necessity, is going the way of the dodo.
Though other studies have suggested this idea may [...]
Tags: Genes, PLOS Genetics, sex chromosomes, X-chromosome, Y-chromosome
Jul
16
2009
The exact causes of Crohn’s disease remain a mystery, but scientists do know that genetic factors play an important part. More than 30 variations have been associated with increased risk for the disease, but changes in one gene, NOD2, have been found to be especially critical. Three different variants in this gene have been associated [...]
Tags: Case Western Reserve University, Crohn's, drug development, ITCH
Dec
29
2008
My surname — Holden — has gone through many incarnations since it originated in England nearly 700 years ago. Letters were added, then dropped. Some branches of my family added an extra “u” in the middle, while others changed the pronunciation entirely. Then, when my ancestors arrived in America over 200 years ago, the name [...]
Tags: forensics, genealogy, Surname, Y-chromosome
Sep
12
2008
23andMe is all about empowering you to really get to know your own DNA. But we also have tools that let you share and compare your data with family and friends.
All you need to do to share your genome with another person is send an invitation from the Genome Sharing page of your account. [...]
Tags: Sharing
Jul
10
2008
You’ve always known that you have your dad’s curly hair, your mother’s eyes, and your grandmother’s coloring. But now that you’ve got your data back from 23andMe, you find yourself wondering whose side of the family the wet ear wax comes from (everyone denies having it), as well as whom to thank for the malarial [...]
Tags: 23andMe, adoption, ancestry, family tree, histocompatibility, HLA system, inheiritance
Jul
03
2008
Last month I had the opportunity to go to the Society of Molecular Biology and Evolution conference in the striking city of Barcelona. This is the premiere conference for geneticists studying evolution in everything from bacteria to fruit flies, weeds, worms and our favorite model organism, humans! This is a highly interactive conference: almost everyone [...]
Tags: 454, FOXP2, human origins, neanderthal, out of africa, paabo
Jul
01
2008
Last month I had the opportunity to go to the Society of Molecular Biology and Evolution conference in the striking city of Barcelona. This is the premiere conference for geneticists studying evolution in everything from bacteria to fruit flies, weeds, worms and our favorite model organism, humans! This is a highly interactive conference: almost everyone [...]
Tags: Duffy, evolution, FOXP2, genetics, HapMap, HGDP, Imprinting, Lactose Intolerance, LCT, Malaria, SMBE