Comments on: SNPwatch: Researchers Link Common Genetic Variations To Those Changes A Woman’s Body Goes Through http://spittoon.23andme.com/2009/05/18/snpwatch-researchers-link-common-genetic-variations-to-those-changes-a-womans-body-goes-through/ A receptacle for genetic knowledge. Sat, 13 Feb 2010 03:51:43 +0000 http://wordpress.org/?v=2.9 hourly 1 By: ErinC http://spittoon.23andme.com/2009/05/18/snpwatch-researchers-link-common-genetic-variations-to-those-changes-a-womans-body-goes-through/comment-page-1/#comment-1845 ErinC Wed, 20 May 2009 16:49:30 +0000 http://spittoon.23andme.com/?p=3606#comment-1845 The two SNPs, rs314276 and rs314263, are located very close together in the genome. In fact, they are close enough that according to our European reference set they always travel together from parent to child. The version of rs314276 that is associated with earlier menarche and the T version of rs314263 seem to always get passed down together as a pair, so we feel confident in telling you that rs314263 can be used as a substitute for rs314276. As you read more SNPwatch posts here in the Spittoon, you'll see that we often use proxy SNPs when the variation reported in a paper is not currently available on the 23andMe SNP chip. The two SNPs, rs314276 and rs314263, are located very close together in the genome. In fact, they are close enough that according to our European reference set they always travel together from parent to child. The version of rs314276 that is associated with earlier menarche and the T version of rs314263 seem to always get passed down together as a pair, so we feel confident in telling you that rs314263 can be used as a substitute for rs314276. As you read more SNPwatch posts here in the Spittoon, you’ll see that we often use proxy SNPs when the variation reported in a paper is not currently available on the 23andMe SNP chip.

]]> By: Phantom http://spittoon.23andme.com/2009/05/18/snpwatch-researchers-link-common-genetic-variations-to-those-changes-a-womans-body-goes-through/comment-page-1/#comment-1841 Phantom Tue, 19 May 2009 20:33:35 +0000 http://spittoon.23andme.com/?p=3606#comment-1841 You say that "Ong et al. actually looked at rs314276, but we’re focusing on rs314263, a perfect proxy for the original". Could you explain that a little more? How is one SNP a proxy for another? How can we know if it's a perfect vs. partial proxy? You say that “Ong et al. actually looked at rs314276, but we’re focusing on rs314263, a perfect proxy for the original”.

Could you explain that a little more? How is one SNP a proxy for another? How can we know if it’s a perfect vs. partial proxy?

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