Having one copy of the G2385R mutation would mean having the AG genotype at rs34778348. Two copies would mean that your genotype is AA. One copy of the G2019S mutation means having the AG genotype at rs34637584. Two copies means a genotype of AA.

You may be interested to know that the G2019S LRRK2 mutation is found at higher than average rates in Norwegians. Check out the Frontline special “My Father, My Brother and Me” (http://www.pbs.org/wgbh/pages/frontline/parkinsons) in which reporter Dave Iverson recounts his family’s experience with Parkinson’s. At one point a researcher tells him that scientists suspect that the LRRK2 mutation spread from North Africa to Norway through the Vikings, who are known to have lived in and around Carthage in about 1000 A.D., leading Iverson to wonder, “Did my own family’s Parkinson’s saga begin a thousand years ago, when some seafaring relative came calling in Carthage?”

Although my odds on 23 and me were in the “typical range”, would having +markers in both put me at an increased risk due to genetics? My paternal grandmother ( hawaiian/chinese) and grandfather ( norwegian) . My grandmother and father both developed Parkinsons’ in their late 70’s. They are both deceased.

Would being + at both markers account for an increased risk as opposed to just + at one marker ? Much thanks…L