Comments on: SNPwatch: Number of SNPs Associated with Crohn’s Disease Triples http://spittoon.23andme.com/2008/06/30/snpwatch-number-of-snps-associated-with-crohn%e2%80%99s-disease-triples/ A receptacle for genetic knowledge. Fri, 20 Nov 2009 04:01:10 -0800 http://wordpress.org/?v=2.8.4 hourly 1 By: nick http://spittoon.23andme.com/2008/06/30/snpwatch-number-of-snps-associated-with-crohn%e2%80%99s-disease-triples/comment-page-1/#comment-501 nick Thu, 31 Jul 2008 16:45:55 +0000 http://spittoon.23andme.com/?p=310#comment-501 "These [SNPs] explain only about a fifth of the genetic risk, which implies that there may be hundreds of genes implicated in the disease..." I can't help but wonder how this might be explained evolutionarily. Hundreds of genes working in concert to create a condition that severely hampers ones fitness? Come on Occam's razor, there's got to be a better unifying explanation... “These [SNPs] explain only about a fifth of the genetic risk, which implies that there may be hundreds of genes implicated in the disease…”

I can’t help but wonder how this might be explained evolutionarily. Hundreds of genes working in concert to create a condition that severely hampers ones fitness? Come on Occam’s razor, there’s got to be a better unifying explanation…

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